Meg 21

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Glycation

One of the most visible signs of premature aging occurs in the skin, where once firm, healthy collagen strands give way to wrinkling, dryness, and looseness. While external factors such as sun exposure can accelerate extrinsic skin aging, scientific evidence points to another culprit: glucose-driven intrinsic aging. Glucose is a vital cellular fuel. However, based on the accelerated rate of aging seen in diabetics,1 chronic glucose exposure has long been known to affect how the body ages by a process called glycation.

Fortunately, nature has also provided nutrients that when applied topically, can overcome skin glycation, leaving firmer, younger-looking skin. Here, we take a look at how these promising ingredients can strengthen collagens regenerative ability and help slow down intrinsic skin aging.

While conducting research on a novel technology that could improve the lives of cancer patients and diabetics, a team of scientists at the Fox Chase Cancer Center in Philadelphia, Pennsylvania discovered the presence of 3-deoxyglucosone (3DG) in skin. The NIH-funded research uncovered the link between 3DG, skin aging, collagen depletion, and loss of skin elasticity. The Fox Chase scientists then discovered how to control 3DG. The MEG 21 moisturizing, anti-aging and anti-wrinkle products incorporate the discovery.

100% of trial participants report that:

skin looks younger
skin is smoother
skin moisture is increased
the cream feels great

	Laboratory research demonstrates that 3DG is present in skin and causes: inflammation decreased production of collagen collagen and elastin cross-linking formation of Advanced Glycation End products (AGEs) oxidative stress and free radicals These all contribute to skin aging.

Dynamis Skin Science is a division of Dynamis Therapeutics, Inc., an early stage pharmaceutical company. Dynamis Therapeutics was founded in 1997 by a team of scientists . The company scientists originally focused on the discovery and development of therapeutic pharmaceuticals to treat and prevent diabetic complications resulting from glucose induced glycation and oxidative stress.

While testing compounds that might reduce these complications in diabetes, scientists from Philadelphia's Fox Chase Cancer Center unexpectedly noticed that a test compound had favorable effects on the texture and elasticity of skin. Further research and development resulted in Supplamine^®, which address the effects on skin resulting from glycation and oxidative stress. Glycation is a process by which proteins, certain fats, and glucose tangle together. It affects all body tissues, and tends to make them stiff and inflexible. Glycation causes most problems for organs where flexibility is most important, such as the heart, kidneys, skin and eyes. As a result, Dynamis Skin Science division was established in 2006 to develop and market topical products containing Supplamine^® to doctors and skin care professionals.