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One of the most visible signs of premature aging occurs in the skin, where once firm, healthy collagen strands give way to wrinkling, dryness, and looseness.
While external factors such as sun exposure can accelerate extrinsic
skin aging, scientific evidence points to another culprit: glucose-driven intrinsic aging. Glucose is a vital cellular fuel. However, based on the accelerated rate of aging seen in diabetics,1 chronic glucose exposure has long been known to affect how the body ages by a process called glycation. Fortunately, nature has also provided
nutrients that when applied topically, can overcome skin glycation,
leaving firmer, younger-looking skin. Here, we take a look at how these
promising ingredients can strengthen collagens regenerative ability and
help slow down intrinsic skin aging.
||Dynamis Skin Science is a division of Dynamis Therapeutics, Inc., an
early stage pharmaceutical company. Dynamis Therapeutics was founded in
1997 by a team of scientists . The company scientists
originally focused on the discovery and development of therapeutic
pharmaceuticals to treat and prevent diabetic complications resulting
from glucose induced glycation and oxidative stress.
While testing compounds that might reduce these complications in
diabetes, scientists from Philadelphia's Fox Chase Cancer Center
unexpectedly noticed that a test compound had favorable effects on the
texture and elasticity of skin. Further research and development
resulted in Supplamine®, which address the
effects on skin resulting from glycation and oxidative stress. Glycation is a process by which proteins, certain fats, and glucose tangle together. It affects all
body tissues, and tends to make them stiff and inflexible. Glycation causes most problems for organs
where flexibility is most important, such as the heart, kidneys, skin and eyes. As a
result, Dynamis Skin Science division was established in 2006 to develop
and market topical products containing Supplamine®
to doctors and skin care professionals.